At Shriners Hospitals for Children—Cincinnati, the health and safety of our patients, families, volunteers and staff is our top priority. With the rapidly evolving situation regarding coronavirus (COVID-19,) we are closely monitoring local health departments and The Centers for Disease Control and Prevention (CDC,) and are actively following their recommendations.

We are working diligently to reschedule appointments postponed during the quarantine. We also understand you may feel some anxiety about bringing your child into the hospital. Our plans to restart routine care have been thoughtfully developed and implemented to keep everyone safe. We are also scheduling some appointments for new patients. If you have any questions, please call the hospital at 855-206-2096.

Families that have appointments of any kind are asked to arrive with ONLY ONE parent or guardian and no additional family members or guests.

When you arrive for your appointment, if you and your child are not already wearing a mask, you will receive one. You will both be screened for illness and will notice new safety precautions in place to promote clean hands, a clean environment, and social distancing.

We are here for you, and look forward to seeing you soon.


Our research

Research is an integral part of Shriners Hospitals for Children — Cincinnati. Our mission is to discover new knowledge that improves the quality of care and quality of life for children and families. Research projects are partially or fully supported by Medical Research Grants from the Shriners Hospitals for Children — Cincinnati. The Cincinnati Research Center focuses on four broad areas that have critical roles in recovery from burn injury:

Wound healing

Skin substitutes for burn wound closure

After a burn, wound closure is a critical part of recovery. Burns that destroy part of the upper layer of skin, the epidermis, can usually heal without skin grafting. However, when burns destroy both layers of skin, the epidermis and the dermis, skin grafting is required for healing. In patients with very large burns, skin substitutes can help speed healing and recovery by providing additional material for skin grafting.

Engineered skin substitutes are made through a process called “tissue engineering.” This involves the isolation of cells from a patient’s unburned skin. These cells are combined with a “scaffold,” such as collagen, to provide structural support, and are cultured in the lab to form a skin-like tissue.

Skin substitutes previously developed by scientists at Shriners Hospitals for Children — Cincinnati were made using two critical cell types: keratinocytes from the epidermis (upper skin layer) and fibroblasts from the dermis (lower skin layer). Clinical trials showed the potential for engineered skin to help healing in patients with very large burns. However, the color of the healed skin substitutes was not a good match for the patients’ natural skin color, and structures such as hair were not present.

Current studies are developing and testing more complex skin substitutes that include other cell types, in addition to keratinocytes and fibroblasts. Next-generation skin substitutes will contain melanocytes, which are pigment-producing cells, to regulate skin color, and hair follicle stem cells, for regrowth of hair. This research will lead to skin substitutes that look and function more like natural skin.

Scarring is a natural part of the healing process. Unfortunately, burns can result in abnormal scars including hypertrophic scars that reduce overall quality of life. Hypertrophic scars are thick, raised scars that can be itchy, painful, and restrict a patient’s range of motion. Researchers are studying two of the most common treatments—compression garments and laser therapy–to help determine the best way to treat and prevent hypertrophic scars after burns.

Immunology, inflammation, and infection

Research at Shriners Hospitals for Children — Cincinnati aims to understand how the body’s immune system responds to burn injury and fights infection. Burn injury can cause massive changes to the entire immune system, resulting in reduced immune function, increased susceptibility to infection, and excessive inflammation, which can lead to death if not properly controlled. Research seeks to understand these processes for development of better therapies for burn patients.


Meeting the nutritional needs of burn patients can be challenging because of the metabolic changes that occur after burns. Nutrition researchers have studied and tested formulations with various levels and types of proteins, fats, vitamins, minerals, probiotics, and fiber to determine the best combination to help improve recovery in burn patients. One formulation developed at Shriners Hospitals for Children — Cincinnati has been commercially developed and is being sold under the trade name IMPACT™. It is currently used to improve outcomes in surgical and trauma patients.

Nutrition researchers and clinicians are interested in the development of nutritional supplements that reduce inflammation and fight infections in burned individuals. Dietary components that boost immune function are called immunonutrients. Recent studies showed that some of the nutrients supplied in IMPACT™ might be immunonutrients. Some immunonutrients, such as fish oil and arginine, may help reduce inflammation and fight wound infection. They could potentially be used to help diseases involving inflammation, such as cardiovascular disease and type II diabetes. Current studies aim to test immunonutrients in humans to determine their safety and effectiveness.


Sleep is also vital for optimum recuperation from injury and illness. For patients with severe burns, getting sufficient sleep is difficult. Studies at Shriners Hospitals for Children — Cincinnati are unraveling the causes and effects of sleep deficiency after burns.

Researchers evaluate sleep using a painless test called polysomnography, which involves measuring brain waves, muscle tension, and eye movements using electrodes attached to the face and head. This test has been used to show that burn injury affects a patient’s internal clock, known as the circadian rhythm. This contributes to sleep deprivation, a problem that continues long after the burn wound has healed.

The Cincinnati’s research team is examining different types of interventions, such as sleep medications and alternative medicine approaches, to increase the time spent in deep, restorative sleep. This research will help determine new approaches for maximizing the quality of sleep, and, consequently, improve the outcomes in children recovering from burns.

Who we are

Leadership & administration

Petra Warner, MD Hospital Chief of Staff Burn surgery
Dorothy Supp, Ph.D. Director of Research
Denise Byrum, MS Research Operations Coordinator

Scientific staff research interests

George Babcock, PhDimmunology, infection, microvesicles Kevin Bailey, MD – plastic surgery, scar reduction Ambi Balasubramaniam, PhDmuscle wasting, burn metabolism Samantha Brugmann, PhD — cleft lip and palate, developmental biology Steven Boyce, PhDskin tissue engineering, scar reduction
Charles Caldwell, PhDimmunology, infection Philip Chang, MD — burn surgery Jason Gardner, PhDimmunology, infection Dan Healy, PharmD – antimicrobial pharmacokinetics, pharmacodynamics David Hildeman, PhD – immunology, infection
J. Howard James, PhD – burn metabolism Rulang Jiang, PhD — cleft lip and palate, developmental biology W. John Kitzmiller, MD – plastic surgery, scar reduction Yu Lan, PhD — cleft lip and palate, developmental biology Francis McCormack, MD – lung disease, lung infection Heather Powell, PhD – skin tissue engineering, scar reduction
Timothy Pritts, MD, PhD – surgery, inflammation, microvesicles Scott Rapp, MD — plastic surgery Latha Satish, PhD — stem cell biology, scar reduction Stacey Schutte, PhD — bioengineering, skin tissue engineering Sulaiman Sheriff, PhD – muscle wasting, burn metabolism Dorothy Supp, PhDskin tissue engineering, scar reduction

Burn research in Cincinnati

Read “Research that Changes Lives: A look at burn research in Cincinnati”
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