Rulang Jiang, MS, PhD

Job Title: Professor of Pediatrics

Department: Department of Pediatrics, University of Cincinnati College of Medicine and Divisions of Developmental Biology and of Plastic Surgery, Cincinnati Children’s Hospital Medical Center

Email: [email protected]

Research Interests: Genetic basis and developmental mechanisms of craniofacial malformations including cleft lip and/or cleft palate, hemifacial microsomia, micrognathia, tooth agenesis.

Biography: Rulang Jiang, PhD, is a developmental biologist directing research programs in craniofacial biology. His lab generates and uses mutant mouse models to investigate the genetic basis and developmental mechanisms of craniofacial disorders, including cleft lip, cleft palate, hemifacial microsomia, micrognathia, tooth agenesis, and other craniofacial deformities. His lab also studies development of the tendons and ligaments, and heterotopic ossification. Following his doctoral and postdoctoral training, Dr. Jiang joined the faculty at University of Rochester School of Medicine and Dentistry in 1999 as a tenure-track Assistant Professor and was promoted to tenured Associate Professor in 2004 and Full Professor in 2009. He has been the principal investigator of craniofacial developmental biology research programs continuously supported by the US National Institutes of Health since 2000. He and his research team were recruited to Cincinnati in 2011.

Education and Training:

B.S. (Biology), Nanjing Normal University, Nanjing, China, 1984.
M.S. (Genetics), Chinese Academy of Sciences, Beijing, China, 1987.
Ph.D. (Biology), Wesleyan University, Middletown, Connecticut, USA, 1995.
Postdoctoral (Developmental Biology), Roche Institute of Molecular Biology, Nutley, New Jersey, USA, 1995.
Postdoctoral (Mammalian Developmental Genetics), The Jackson Laboratory, Bar Harbor, Maine, 1998.

Publications in the last five years:

Bush, J.O. and Jiang, R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development 139:231-243, 2012.

Yu, C.-T., Tang, K., Suh, J. M., Jiang, R., Tsai, S. Y., Tsai, M.-J. COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival. Development 139:2330-2339, 2012.

Guillot, N., Kollins, D., Gilbert, V., Xavier, S., Chen, J., Gentle, M.E., Reddy, A., Bottinger, E.P., Jiang, R., Rastaldi, M., Corbelli, A., Schlondorff, D.O. BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGF signaling. PLoS One 7:e39406, 2012.

Anderson, D.M., George, R., Noyes, M.B., Rowton, M., Liu, W., Jiang, R., Wolfe, S.A., Wilson-Rawls, J., Rawls, A. Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor. J. Biol. Chem. 287:35351-35359, 2012.

Bae, C.H., Lee, J.Y., Kim, T.H., Baek, J.A., Yang, X., Taketo, M.M., Jiang, R., Cho, E.S. Excessive Wnt/beta-catenin signaling disturbs tooth root formation. J. Periodontal Res. 48 (4): 405-410, 2013.

Zhu, S., Chen, K., Lan, Y., Zhang, N., Jiang, R., Hu., J. Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats. Bone 53 (2): 340-349, 2013.

Kim, T-H., Bae, C-H., Lee, J-C., Ko, S-O., Yang, X., Jiang, R., Cho, E-S. -catenin is required in odontoblasts for tooth root formation. J. Dent. Res. 92 (3): 215-221, 2013.

Jia, S., Zhou, J., Gao, Y., Baek, J.-A, Martin, J. F., Lan, Y., Jiang, R. Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development 140:423-432, 2013.

Zhou, J., Gao, Y., Lan, Y., Jia, S., Jiang, R. Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development 140:4709-4718, 2013.

Liu, H., Lan, Y., Xu, J., Chang, C. F., Brugmann, S. A., Jiang, R. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proceedings of the National Academy of Sciences USA 110:18555-18560, 2013.

Lan, Y., Jia, S., Jiang, R. Molecular patterning of the mammalian dentition. Seminars in Cell and Developmental Biology 25-26:61-70, 2014.

Zhou, H., Zou, S., Lan, Y., Fei, W., Jiang, R., Hu, J. Smad7 modulates TGF-beta signaling during cranial suture development to maintain suture patency. J. Bone Min. Res. 29:716-724, 2014.

Xu, J., Liu, H., Park, J. S., Lan, Y., Jiang, R. Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development 141: 1442-1452, 2014.

Liu, H., Xu, J., Liu, C-F., Lan, Y., Wylie, C., Jiang, R. Whole transcriptome expression profiling of mouse limb tendon development by using RNA-seq. Journal of Orthopaedic Research 33:840-848, 2015.

Breidenbach, A.P., Aschbacher-Smith, L., Lu, Y., Dyment, N.A., Liu, C.F., Liu, H., Wylie, C., Rao, M., Shearn, J.T., Rowe, D.W., Kadler, K.E., Jiang, R., Butler, D.L. Ablating hedgehog signaling in tenocytes during development impairs biomechanics and matrix organization of the adult murine patellar tendon enthesis. Journal of Orthopaedic Research 33:1142-1151, 2015.

Kwon, H-J, Park, E-K, Jia, S, Liu, H, Lan, Y, Jiang, R. Deletion of Osr2 partially rescued tooth development in Runx2 mutant mice. Journal of Dental Research 94:1113-1119, 2015.

Dyment, N.A., Breidenbach, A.P., Schwartz, A.G., Russell, R.P., Aschbacher-Smith, L., Liu, H., Hagiwara, Y., Jiang, R., Thomopoulos, S., Butler, D.L., Rowe, D.W. Gdf5 progenitors give rise to fibrocartilage cells that mineralize via Hedgehog signaling to form the zonal enthesis. Developmental Biology 405:96-107, 2015.

Lan, Y., Xu, J., and Jiang, R. Cellular and Molecular Mechanisms of Palatogenesis. Current Topics in Developmental Biology (Craniofacial Development) 115:59-84, 2015.

Xu, J., Liu, H., Lan, Y., Aronow, B.J., Kalinichenko, V.V., Jiang, R. A Shh-Foxf-Fgf18-Shh molecular circuit regulating palate development. PLOS Genetics 12(1):e1005769, 2016.

Lan, Y., Zhang, N., Liu, H., Xu, J., Jiang, R. Golgb1 regulates protein glycosylation and is crucial for mammalian palate development. Development 143(13):2344-55, 2016.

Xu, J., Liu, H., Chai, O.H., Lan, Y., Jiang, R. Osr1 interacts synergistically with Wt1 to regulate kidney organogenesis. PLOS One 11(7): e0159597, 2016.

Jia, S., Kwon, H-J.E., Lan, Y., Zhou, J., Liu, H., Jiang, R. Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Developmental Biology 420 (1):110-119, 2016.

Grants:

“Molecular Regulation of Palate Development”, Shriners Hospitals for Children Grant #85900 (Jiang),  01/01/2017 – 12/31/2021

“Molecular Patterning of Mammalian Dentition”, NIH R01 DE18401 (Jiang), 09/20/2013 – 6/30/2018.

“Osr Transcription Factors Regulate Embryonic Lung Development”, NIH R01 HL114898 (Zorn), 08/10/2012 – 06/30/2017.

Translate »