Michele M. Gottschlich, PhD, RD, CNSD, PSGT, CSP, CCRP

Research Interests

Nutrition support in critical care, burns and cleft lip and palate; Sleep medicine; Breast feeding; Integrative medicine, Vitamin D, Melatonin

Biography

Positions

2008 – Present Adjunct Associate Professor, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH

1984 – Present Director, Nutrition Services/Clinical Research Scientist, Shriners Hospitals for Children, Cincinnati, OH

1998 – 2006 Clinical Instructor, School of Allied Medical Professions, The Ohio State University, Columbus, OH

1987 – 2004 Adjunct Associate Professor, Department of Health & Nutrition Science, University of Cincinnati, Cincinnati, OH

1979 – 1983 Critical Care Dietitian, Miami Valley Hospital, Dayton, OH

Other Experience

1996 – Present Editor, Nutrition Forum, Journal of Burn Care & Research

2003 – 2015 Editorial Board, Nutrition in Clinical Practice

2000 – 2004 Board of Trustees, American Burn Association

1995 – 2009 Co-Editor, Contemporary Nutrition Support Practice, WB Saunders Co., 1st  

             & 2nd Editions.

1998 – 2007 Editor-in-Chief, Interdisciplinary Core Curriculum, American Society for

             Enteral and Parenteral Nutrition, Kendall-Hunt Publishing Co., 1st & 2nd Editions

1997 – 2004 Board of Editors, Journal of American Dietetic Association

1995 – 1998 Co-Editor, Practice-Oriented Nutrition Research: An Outcome Measurement

             Approach, Aspen Publishers

1993 – 1994 Board of Directors, American Society for Parenteral and Enteral Nutrition

1989 – 1993 Co-Editor, Nutrition Support Dietetics Core Curriculum, 2nd Edition,                    

               American Society for Parenteral and Enteral Nutrition

Honors

1989, 1992 American Society for Parenteral and Enteral Nutrition Dietitian Research     

         Awards

1994 Journal of American Dietetic Association Huddleson Award for best journal

         manuscript

1995 American Dietetic Association Foundation Award for Excellence in Dietetic

         Research

1997 ASPEN Distinguished Achievement in Nutrition

1994, 2002 American Burn Association Clinical Research Awards

2007 Ohio Society for Parenteral and Enteral Nutrition Poster Award

2008 Business Courier’s Health Care Hero Innovation Award

2008 American Burn Association Curtis P. Artz Distinguished Service Award

2010 American Burn Association Poster Award

1994, 2012 Ohio Dietetic Association Research Dietitian Awards

2015 Frank F. Ferris II Planning Award, Hamilton County Regional Planning Commission

2016 Hamilton County Public Health WeTHRIVE Community Health Champion

2016 Chamber of Commerce and Village of Evendale Outstanding Service Award

Professional Memberships

American Academy of Sleep Medicine (AASM)

American Burn Association (ABA)

Academy of Nutrition and Dietetics (formerly American Dietetic Association)

American Society for Parenteral and Enteral Nutrition (ASPEN)

International Society for Burn Injuries (ISBI)

European Society for Parenteral and Enteral Nutrition (ESPEN)

Society for Clinical Data Management (SCDM)

Society for Clinical Research Excellence (SOCRA)

Contributions to Science:

  1. Early research and corresponding publications focused on translation of bench research to clinical development of a tube feeding formula (high protein, low fat, enriched with arginine and omega-3 fatty acids) for pediatric burn patients. This innovative recipe demonstrated reduced infection and shortened hospital stay, prompted the notion of “immunonutrition,” and precipitated the marketing of enteral immune-enhancing products by pharmaceutical companies. Shriners Hospitals (SHC) received more revenue from this patent than all other SHC patents combined. Pursued methods to improve composition of disease-specific feeding as evidenced by our more recent work with Oxepa® and probiotics.
  • Gottschlich MM, Jenkins M, Warden GD, Baumer T, Havens P, Snook JT, Alexander, JW. Differential Effects of Three Enteral Regimens on Selected Outcome Parameters in Burn Patients. JPEN, 1990;14:225-236.
  • Alexander JW, Gottschlich M. Nutritional Immunomodulation in Burn Patients. Crit Care Med, 1990;18:S149-S153.
  • Gottschlich MM. Selection of Optimal Lipid Sources in Enteral and Parenteral Nutrition. Nutr Clin Pract, 1992;7:152-166.
  • Jenkins ME, Gottschlich MM, Khoury J, Warden GD. A Prospective Analysis of Serum Vitamin K and Dietary Intake in Severely Burned Pediatric Patients. J Burn Care Rehabil, 1998;19:75-81.
  • Mayes T, Gottschlich M, Kagan RJ. An Evaluation of the Safety and Efficacy of an Anti-inflammatory, Pulmonary Enteral Formula in the Treatment of Pediatric Burn Patients with Respiratory Failure. J Burn Care Res, 2008;29:82-88.
  • Mayes T, Gottschlich MM, James L, Allgeier C, Weitz J, Kagan RJ. Clinical Safety and Efficacy of Probiotic Administration Following Burn Injury. J Burn Care Res 2015;36:92-99.
  1. Provided landmark evidence that the sooner that post pyloric enteral nutrition support is initiated the better. Also demonstrated that continued enteral feeding is safe even during operative procedures in association with positive outcomes. Revolutionary practice improvements have been delineated as a result of clinical findings elucidating important adjustments to maximize safety (e.g. prevent bowel necrosis, reduce radiation exposure and minimize bacterial growth of feeding substrate). Furthermore, these clinical practice techniques including early feeding and intraoperative research have significantly impacted clinical nutrition standards of practice internationally. Recipient of the American Burn Association Clinical Research Award as a direct result of this work.
  • Gottschlich MM, Warden GD, Michel MA, Havens P, Kopcha R, Jenkins M, Alexander JW. Diarrhea in Tube-Fed Burn Patients: Incidence, Etiology, Nutritional Impact and Prevention. JPEN, 1988;12:338-345.
  • Jenkins ME, Gottschlich MM, Baumer T, Khoury J, Warden GD. Enteral Feeding During Operative Procedures. J Burn Care Rehabil, 1994;15:199-205.
  • Gottschlich MM, Jenkins ME, Mayes T, Khoury J, Kagan RJ, Warden GD. An Evaluation of the Safety of Early Versus Delayed Enteral Support and Effects on Clinical, Nutritional and Endocrine Outcomes after Severe Burns. Awarded the American Burn Association’s Clinical Research Award. J Burn Care Rehabil, 2002;23:401-415.
  • Neely AN, Mayes T, Gardner J, Gottschlich MM. A Microbiological Study of Enteral Feeding Hang Time in a Burn Hospital: Can Feeding Costs be Reduced without Compromising Patient Safety? Nutr Clin Pract, 2006:21:610-616.
  • Cone LC, Gilligan MF, Kagan RJ, Gottschlich MM. Enhancing Patient Safety: The Effect of Process Improvement on Bedside Fluoroscopy Time Related to Nasal Duodenal Feeding Tube Placement in Pediatric Burn Patients. J Burn Care Res, 2009;30:606-611.
  1. First to document the presence of significant sleep pattern disturbance in burned children using objective outcome measures (polysomnography and actigraphy) to improve upon the clinical (visual) assessment sleep, resulting in another Clinical Research Award. Further study has characterized the effectors of sleep and the metabolic sequelae of sleep deprivation.
  • Gottschlich MM, Jenkins ME, Mayes T, Khoury J, Kramer M, Warden GD. Kagan RK. A Prospective Clinical Study of the Polysomnographic Stages of Sleep Following Burn Injury. J Burn Care Rehabil 1994;15:486-492.
  • Gottschlich MM, Khoury J, Warden GD, Kagan RJ. An Evaluation of the Neuroendocrine Response to Sleep in Pediatric Burn Patients. JPEN 2009;33:317-326
  • Armour AD, Khoury J, Kagan RJ, Gottschlich MM. Clinical Assessment of Sleep Among Pediatric Burn Patients Does Not Correlate with Polysomnography. J Burn Care Res 2011;32:529-534.
  • Gottschlich MM, Mayes T, Khoury J, McCall J, Simakajornboon N, Kagan RJ. The Effect of Ketamine on Sleep Architecture. J Burn Care Res, 2011;32:535-540.
  • Mayes T, Gottschlich MM, Khoury J, Simakajornboon N, Kagan RJ. Quantity and Quality of Nocturnal Sleep Impact Morning Glucose Measurement in Acutely Burned Children. J Burn Care Res 2013;34:483-491.
  • Gottschlich MM, Mayes, Khoury J, Simakajornboon N, Kagan RJ. Comparison of Sleep Parameters Obtained from Actigraphy and Polysomnography during the Rehabilitative Phase Postburn. J Burn Care Res 2013;34:183-190.
  • Cronin SD, Gottschlich MM, Gose LM, Kagan RJ. Zolpidem and Sleep in Pediatric Burn Patients with Attention Deficit/Hyperactivity Disorder. Pediatric Nursing 2015;41:132-134.
  1. Scientific leader in developing methods (both allopathic and also homeopathic interventions) designed to improve the quantity and quality of sleep in children, including efficacy studies involving healing touch, melatonin (IND #117278) and sleep medications. We recently completed a series of important pharmacokinetic and pharmacodynamic sleep investigations that indicate divided nocturnal medication dosing for critically ill patients is optimal. Additional findings suggest that complementary medicine (such as healing touch, special foods, melatonin and/or light/sound) may represent adjunctive measures to support mainstream sleep medicine.
  • Armour A, Gottschlich MM, Khoury J, Warden GD, Kagan RJ. A Randomized, Prospective Trial of Zolpidem and Haloperidol for Use as Sleeping Agents in Pediatric Burn Patients. J Burn Care Res 2008;29:238-247.
  • Stockmann C, Sherwin CMT, Buterbaugh W, Spigarelli MG, Gottschlich MM, Healy D, Kagan RJ. Zolpidem as a Sleep-Enhancing Agent Used in the Treatment of Severely Burned Children. Therapeutic Drug Monitoring 2014;36(3):295-301.
  • Cone L, Gottschlich MM, Khoury J, Simakajornboon N, Kagan RJ. The Effect of Healing Touch on Sleep Patterns of Pediatric Burn Patients; a Prospective Crossover Trial. J Sleep Disorders: Treatment and Care 2014;3(2):1-6.
  • Stockmann C, Gottschlich MM, Healy D, Khoury JC, Mayes T, Sherwin CMT, Spigarelli MG, Kagan RJ. Relationship between Zolpidem Concentrations and Sleep Parameters in Pediatric Burn Patients. J Burn Care Res 2015;36:137-144.
  • Stockmann C, Spigarelli MG, Healy D, Gottschlich M, Buterbaugh W, Kagan R, Balch A, Sherwin CMT. Application of a Method Used to Deconstruct a Single Dose Pharmacokinetic Profile from Multiple Dose Data. Biopharmaceutics & Drug Disposition. 2015 March 12. [Epub ahead of print].
  1. Demonstrated the pervasive existence of Vitamin D deficiency in children postburn, detailed the morbidity associated with hypovitaminosis D and also conducted dose- and metabolite (e.g. D2 vs D3)- dependent effectiveness trials. More recent is my interest in connecting vitamin D to sleep medicine.
  • Wray C, Mayes T, Khoury J, Warden G, Gottschlich M. Metabolic Effects of Vitamin D on Serum Calcium, Magnesium and Phosphorus in Pediatric Burn Patients. Awarded the American Burn Association’s Moyer Research Award. J Burn Care Rehabil, 2002;23:416-423.
  • Mayes T, Gottschlich M, Scanlon J, Warden GD. A Four-Year Review of Burns as an Etiologic Factor in the Development of Long Bone Fractures in Pediatrics. J Burn Care Rehabil, 2003;24:279-284.
  • Gottschlich MM, Mayes T, Khoury J, Warden GD. Hypovitaminosis D in Pediatric Burn Patients. J Am Diet Assoc, 2004;104:931-941.
  • Mayes T, Gottschlich MM, Khoury J, Kagan RJ. An Investigation of Bone Health Subsequent to Vitamin D Supplementation in Children following Burn Injury. Nutrition in Clinical Practice 2015;30:830-837.
  • Gottschlich MM, Mayes TM, Khoury J, Kagan RJ. Clinical Trial of Vitamin D2 versus D3 Supplementation in Critically Ill Pediatric Burn Patients. J Parent Enter Nutr 2015: Jun 9. pii: 0148607115587948. [Epub ahead of print]. Selected for A.S.P.E.N.’s monthly “Media Alert.”

Complete List of Published Work in MyBibliography: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47712361/?sort=date&direction=ascending

Grants

Ongoing Research Support

Shriners Hospitals for Children (#71000) Gottschlich (PI) 1/1/2015-12/31/2017

Effectiveness of Healing Touch on Sleep, Pain, Anxiety, Anesthesia Emergence, Satisfaction and Cost of Care in Pediatric Surgical Patients.

The goals of this project include determining the efficacy of healing touch on improving measures of sleep in surgical patients. A secondary objective is to establish the value of healing touch on perioperative management of surgery- related outcomes such as pain, anxiety, anesthesia emergence, patient satisfaction and cost of care.

Shriners Hospitals for Children (#84080) Gottschlich (Co Inv) 1/1/2008-12/31/2017

Special Shared Facility-Clinical Research

The goals of this project include the provision of coordination, support and management of clinical research and to catalyze the integration of projects into bedside clinical care routines; with emphasis on building resources to support the clinical researcher, generating knowledge, and impacting healthcare. A clinical database for retrospective, longitudinal and prospective study data utilization is maintained.

Completed Research Support

Shriners Hospitals for Children (#71005) Gottschlich (PI) 1/1/2012-12/31/2016

Diagnosis and Treatment of Dyssomnia in Children during Burn Rehabilitation.

The goals of this study include determining the efficacy of melatonin on improving sleep-related outcomes in outpatients. A secondary objective is to establish valid diagnostic tools (actigraphy, psychomotor vigilance test) in the assessment of sleep in the home during the rehabilitative phase of burn recovery.

Shriners Hospitals for Children (#70097) Gottschlich (PI) 1/1/2009-12/31/2011

Differential Effects of Zolpidem versus Ramelteon on Nocturnal Sleep in Pediatric Burn Patients: A Prospective, Randomized Crossover trial with Polysomnographic Recordings. This study compared the polysomnographic changes associated with sleep following various therapeutic drug interventions and we related those changes to drug pharmacokinetics, pharmacodynamics, endocrine, nutrition, metabolism, pain and additional clinical outcomes in pediatric burn patient.

Contact

Michele M. Gottschlich, PhD, RD, CNSD, PSGT, CSP, CCRP
Clinical Research Investigator/Pediatric Nutrition Specialist
Research Department
Shriners Hospital for Children

Adjunct Associate Professor
Department of Surgery
University of Cincinnati
[email protected]

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