Dorothy M. Supp, Ph.D.

Research interests

Skin biology and wound healing: molecular biology of keloid and hypertrophic scars, including development of novel treatment and prevention strategies; organotypic in vitro and in vivo scar models; preclinical assessment of scar therapies, including compression and laser therapy; vitamin D and scar formation; eicosanoids and angiogenesis in wound healing Tissue engineering and regenerative medicine: development of next-generation skin substitutes, including engineered skin with natural pigmentation, de novo hair follicle development, and neovasculogenesis; epidermal stem cell identification and propagation; cutaneous gene therapy for epidermolysis bullosa; organotypic models for melanoma research.

Biography

Dr. Supp was born and raised in Yonkers, New York and attended Cornell University. She moved to Cincinnati, OH to pursue graduate studies in Developmental Biology at the University of Cincinnati and Cincinnati Children’s Hospital Research Foundation. Her research interests have been focused on wound healing since 1997 when she was awarded a research fellowship at the Cincinnati Shriners Burns Hospital. In 2000 she was awarded her first independent medical research grant from Shriners; since then, her research has been continuously supported by grant funding from the Shriners Hospitals for Children. She remains dedicated to the mission of the Shriners Hospitals and continues to pursue translational research aimed at improving the lives of children with burns, scars, and congenital skin diseases.

Education and training

  • B.S., Biology, Cornell University, Ithaca, NY
  • Ph.D., Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, OH
  • Postdoctoral Fellowship, Perinatology, Children’s Hospital Research Foundation, Cincinnati, OH
  • Research Fellowship, Tissue Engineering, Shriners Hospitals for Children, Cincinnati, OH

Publications

Selected recent publications
  1. Supp DM. Animal Models for Studies of Keloid Scarring. Accepted for publication in Adv Wound Care; 8/30/18.
  2. DeBruler DM, Baumann ME, Blackstone BN, Zbinden JC, McFarland KL, Bailey JK, Supp DM, Powell HM. Role of early application of pressure garments following burn injury and autografting. Accepted for publication in Plast Reconstruct Surg; 6/1/18.
  3. Blackstone BN, Hahn J, McFarland KL, Dunham DM, Supp DM, Powell HM. Inflammatory Response to Coaxial Scaffolds Reduces Engineered Skin Mechanics Post-Grafting. Acta Biomaterialia; 80(2018): 247-257.
  4. DeBruler DM, Zbinden JC, Baumann ME, Blackstone BN, Malara MM, Bailey JK, Supp DM, Powell HM. Early cessation of pressure garment therapy results in scar contraction and thickening. PLOS One; 2018 Jun 13;13(6):e0197558. PMID: 29897933.
  5. DeBruler DM, Blackstone BN, McFarland KL, Baumann ME, Supp DM, Bailey JK, Powell HM: Effect of skin graft thickness on scar development in a porcine burn model. Burns 2018;44(4):917-930. PMID: 29661554.
  6. Malara MM, Kim JY, Clark JA, Blackstone BN, Ruegsegger M, Bailey JK, Supp DM, Powell HM. Structural, chemical and mechanical properties of pressure garments as a function of simulated use and repeated laundering. J Burn Care Res 2018;39(4):562-571. PMID: 29901806.
  7. Bailey JK, Blackstone BN, DeBruler DM, Kim JY, Baumann ME, McFarland KL, Imeokparia FO, Supp DM, Powell HM. Effects of early combinatorial treatment of autologous split-thickness skin grafts in red Duroc pig model using pulsed dye laser and fractional CO2 laser. Lasers Surg Med 2017;50(1):78-87. PMID: 28759110.
  8. Boyce ST, Lloyd C, Kleiner M, Swope V, Abdel-Malek Z, Supp DM. Restoration of cutaneous pigmentation by transplantation of isogeneic epidermal melanocytes in dermal-epidermal engineered skin substitutes. Pigment Cell Melanoma Res 2017; 30(6):531-540. PMID: 28640957.
  9. Blackstone BN, Kim JY, McFarland KL, Sen CK, Supp DM, Bailey JK, Powell HM: Scar formation following excisional and burn injuries in a red Duroc pig model. Wound Rep Regen 2017; 25(4):618-631. PMID: 28727221.
  10. Hahn JM, Supp DM. Abnormal expression of the vitamin D receptor in keloid scars. Burns, 2017; 43(7):1506-15. PMID: 28778755.
  11. Sethuraman SA, Gottschlich MM, Supp DM, Khoury J, Kagan RJ. Vitamin D biomarkers associated with abnormal scar formation in pediatric burn patients. J Keloid Res 2017; 1(1):August 30.
  12. Lander JM, Supp DM, He H; Martin LJ, Chen X, Weirauch MT, Boyce ST, Kopan R. Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers. PLoS ONE 2017;12(9): e0184500. PMID: 28953906.
  13. DeBruler DM, Blackstone BN, Baumann BE, McFarland KL, Wulff BC, Wilgus TA, Bailey JK, Supp DM, Powell HM. Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO2 laser treatment of burn scars. Lasers Surg Med 2017; 49(7):675-685. PMID: 28489283.
  14. Boyce ST, and Supp DM: Biologic Skin Substitutes. In: Skin Tissue Engineering and Regenerative Medicine, Holmes JH and Albanna MZ, Eds. Elsevier, Inc., Waltham, MA. 2016.
  15. Supp DM, Hahn JM, McFarland KL, Combs KA, Lee KSS, Inceoglu B, Wan D, Boyce ST, Hammock BD: Soluble epoxide hydrolase inhibition and topical epoxyeicosatrienoic acid treatment improve vascularization of engineered skin substitutes after transplantation to mice. PRS Global Open 2016; 2016;4(12):e1151. PMID: 28293507.
  16. Hahn JM, McFarland KL, Combs AK, Supp DM: Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1. Burns & Trauma 2016; 4(1):30. PMID: 27574697.
  17. Kim JY, Dunham DD, Supp DM, Sen CK, Powell HM. Novel burn device for rapid, reproducible burn wound generation. Burns 2016; 42(2):384-91. PMID: 26803369.
  18. Kim JY, Willard JJ, Supp DM, Roy S, Gordillo GM, Sen CK, Powell HM. Burn scar biomechanics following pressure garment therapy. Plast Reconstruct Surg, 2015; 136(3):572-581. PMID: 25989300.
  19. Boyce S, Zimmerman R, Supp D: Tumorigenicity testing in athymic mice of cultured human melanocytes for transplantation in engineered skin substitutes. Cell Transplantation 2015; 24(8):1423-1429. PMID: 25199067.
  20. Alexander JW, Supp DM: Role of arginine and omega-3 fatty acids in wound healing and infection. Adv Wound Care 2014;3(11):682-690. PMID: 25371851.
  21. Supp DM, Hahn JM, McFarland KL, Glaser K: Inhibition of hyaluronan synthase 2 (HAS2) reduces the abnormal migration rate of keloid keratinocytes. J Burn Care Res 2014; 35(1):84-92. PMID: 24043232.
  22. Osterburg AR, Hexley P, Supp DM, Robinson CT, Noel G, Ogle C, Boyce ST, Aronow BJ, Babcock GF: Concerns over interspecies transcriptional comparisons in mice and humans after trauma. Proc Natl Acad Sci USA 2013; 110(36):E3370. PMID: 23847210.
  23. Sriwiriyanont P, Lynch K, McFarland KL, Supp D, Boyce S: Characterization of chimeric hair follicle development in human engineered skin substitutes. PLOS One 2013; 8(6):e65664. PMID: 23799033.
  24. Hahn JM, Glaser K, McFarland KL, Aronow BJ, Boyce ST, and Supp DM: Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology. Wound Rep Regen 2013; 21:530-544. PMID: 23815228.
  25. Sriwiriyanont P, Lynch K, Maier E, Hahn J, Supp D, Boyce S: Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells. Exp Dermatol 2012; 21(10):783-5. PMID: 23078401.
  26. Swope V, Jameson J, McFarland K, Supp D, Miller W, McGraw D, Patel MA, Nix MA, Milhauser G, Babcock G, Abdel-Malek ZA:Defining MC1R Regulation in human melanocytes by its agonist α-melanocortin and antagonists agouti signaling protein and β-defensin 3. J Invest Dermatol 2012; 132(9):2255-62. PMID: 22572817.
  27. Boyce ST, Rice RK, Lynch KA, Supp AP, Swope VB, Kagan RJ, and Supp DM: Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice. Wound Rep Regen 2012; 20(4):544-51. PMID: 22672265.
  28. Supp DM, Hahn JM, Glaser K, McFarland KL, Boyce ST: Deep and superficial keloid fibroblasts contribute differentially to tissue phenotype in a novel in vivo model of keloid scar. Plast Reconstruct Surg 2012; 129(6):1259-1271. PMID: 22634643.
  29. Supp DM: Genomic reprogramming and skin-like maturation of engineered human skin substitutes. Adv Wound Care 2012; 1(2):63-68. PMID: 24527282.
  30. Supp DM, Glaser K, Hahn JM, McFarland KL, Boyce ST: Abnormal responses of keloid tissue to wounding identified using in vitro model system. ePlasty 2012; e19. PMID: 22536458.

Grants: current (PI)

Epoxyeicosatrienoic Acids: Therapeutic Potential in Skin Grafting and Burns
Shriners Hospitals for Children #85800-CIN-17
Period of Support: 1/1/17-12/31/20

Targeting Hyaluronic Acid Synthesis to Suppress Abnormal Scarring
Shriners Hospitals for Children #85500-CIN-15
Period of Support: 1/1/15-12/31/19

Medical Research Grant #85102-CIN-18
Shriners Hospitals for Children
Title: “Correction of Epidermolysis Bullosa via Genome Editing and Tissue Engineering”
Period of Support: 1/1/18-12/31/22

Contact

Dorothy M. Supp, Ph.D. Senior Investigator Research [email protected]
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