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Research affiliations

Many scientific instruments, resources, or methods are very expensive—too expensive for a single laboratory to afford. Shared facilities are shared resources or laboratories available for use by multiple researchers, providing a cost-effective way to access high-tech equipment and expensive services. Shriners Hospitals for Children — Cincinnati has multiple shared facilities used by members of the Cincinnati research community, including Shriners Hospitals for Children — Cincinnati, University of Cincinnati, and Cincinnati Children’s Hospital Medical Center.


Flow cytometry shared facility

Flow cytometry has applications in basic research, clinical practice, and clinical trials. A flow cytometer is a sophisticated instrument that uses laser technology to measure various properties of cells, including size and activation state. It can also be used to detect the presence or absence of certain proteins inside cells or on a cell’s surface. The flow cytometry shared facility has the ability to use up to five lasers, which permits measurement of up to 20 different parameters of cells.


Histology shared facility

Histology is the study of the microscopic anatomy of cells and tissues. This usually involves the fixation (to prevent decay) and sectioning (to make ultra-thin slices) of tissue samples to permit detailed structural analysis. Preparation of tissue for histology requires a great deal of training, specialized equipment, and many different types of chemical dyes used to visualize structures within cells.


Clinical research shared facility

Clinical research refers to the testing of new medications, procedures, and devices in patients for safety and efficacy. Clinical research must comply with numerous local and federal regulations to ensure the safe and appropriate treatment of human subjects. Clinical research nurses are knowledgeable about applicable regulations and assist with initiating and conducting clinical trials. Nurses act as liaisons between researchers and clinicians and assist clinicians in planning and conducting experiments in patients, as well as collection and analysis of data.


Data analysis

Data analysis is a critical component of research, whether that research is done at a laboratory bench or in a clinical setting. Statistical analysis uses mathematical methods to identify trends in data and ensures the validity of conclusions drawn from a particular study. For medical and biological research, a biostatistician helps with sample size estimation (determining number of patients needed for a study), data management, and data analysis. The research department employs a staff biostatistician to help researchers involved in both preclinical and clinical research with study design and statistical analysis of data.


Who we are

Karen Domenico
Flow Cytometry

Mary Rolfes, MLT/HT, ASCP
Histology

Laura Fowler, RN, BSN, CCRC
Clinical Research Coordinator

Judy Nelson, RN, CCRC
Clinical Research Nurse

Laura James, MS
Biostatistics

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